SUMOylation相关论文
研究背景胸腺基质淋巴细胞生成素（Thymic stromal lymphopoietin,TSLP）是一种主要来源于上皮细胞的炎症因子,参与哮喘气道炎症的进展......
研究背景:PML核体（PML-NBs）是哺乳动物细胞核内存在的直径从0.1-1μm不等的无膜细胞器。作为一个细胞核内蛋白质富集的场所,已经报道......
人类微小RNA（microRNA,简称miRNA）通过和Ago2蛋白结合形成RISC复合物（RNA-induced silencing complex）,介导mRNA降解和抑制mRNA翻译,发......
The onset of inflammatory bowel disease (IBD) involves many factors, including environmental parameters, microor-ganisms......
Assessment of SENP3-interacting proteins in hepatocytes treated with diethylnitrosamine by BiolD ass
SUMOylation of proteins regulates cell behaviors and is reversibly removed by small ubiquitin-like modifier(SUMO)-specif......
Background:Posttranslationalsumoylationbyconjugatingsmallubiquitin-likemodifier(SUMO)totargetproteinisan evolutionarilyc......
目的 急性髓细胞白血病(acute myeloid leukemia,AML)是我国白血病最常见的类型,发病率约十万分之四,并随着年龄的增长发病率逐年......
会议
Objective It is widely accepted that leukemogenesis results from the accumulation of genetic and epigenetic alteration d......
SUMOylation of hSSB1 stabilizes its protein and enhances its recruiting NBS1 to the DNA damage sites
Objective The integrity of the genome is frequently challenged by various types of DNA damage induced by replication err......
会议
We have previously reported that endogenous (oxysterols) as well as synthetic (GW3965, TO0901317) ligands of Liver X Rec......
SENP3 enhances STAT3 transcriptional activity via deSUMOylation in smoking-related head and neck squ
Chronic exposure to tobacco smoking increases the risk of human head and neck squamous cell cancer (HNSCC).Tobacco smoke......
SUMO-specific protease 2 is critical for the regulation of M-current through PLCb4 and Kv7 pathway d
Sudden unexplained death in epilepsy(SUDEP)is the most common and primary cause of premature mortality in epilepsy.Hyper......
IQGAP1 is a conserved multifunctional protein implicated in tumorigenesis.An aberrant expression of IQGAP1 widely exists......
SAE1 promotes human glioma progression through activating AKT SUMOylation and AKT signaling pathways
The SUMO-activating enzyme SAE1 involves in progression of several human cancers.However,its biological roles of SAE1 in......
IQGAP1 is a conserved multifunctional protein implicated in tumorigenesis by promoting cell proliferation,weakening cell......
hCINAP regulates the DNA damage response and mediates the resistance of acute myelocytic leukemia ce
Maintenance of genomic stability is critical for the proper function of organisms.When DNA damage occurs and is detected......
It is widely accepted that leukemogenesis results from the accumulation of genetic and epigenetic alteration during the ......
The methyl-CpG-binding protein 2(MeCP2)gene,MECP2,is an X-linked gene encoding the MeCP2 protein and mutations of MECP2 ......
The E3 ligase PIAS1 facilitates spatial learning and memory through enhanced SUMOylation of STAT1 an
We have previously found that the protein inhibitor of activated STAT1(pias1)gene is differentially expressed between th......
SUMO proteins differentially regulate the subcellular localization and stability of p65 in HBV-assoc
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肥胖已经成为威胁人类健康的全球健康问题，流行病学调查发现环境污染物暴露与肥胖的发生具有一定的相关性。......
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Human parainfluenza virus type 3(HPIV3),a member of the Paramyxoviridae family,can cause lower respiratory disease in in......
Sudden unexplained death in epilepsy(SUDEP),which is the most common and primary cause of premature mortality in epi......
Aspergillus flavus SUMO, A Novel Modifier of SUMOylation, Contributes to the Fungal Virulence and To
As the modifier in SUMOylation, SUMO can be reversibly attached to target proteins, and influences several important......
It has been shown that the disruption of the SUMOylation system in silkworm induced the defects of holocentric chrom......
The SUMO E3 ligase MdSIZ1 promotes anthocyanin accumulation by sumoylating MdMYB1 under adverse temp
MYB1 is an important transcriptional factor that regulates anthocyanin biosynthesis in red-skinned apples (Malus domesti......
The SUMOylation is one of the critical regulatory protein modifications and plays a pivotal role in cardiac developm......
小泛素相关修饰物（smallubiq uitin related modifier，SUMO）修饰是与泛素化修饰类似的蛋白质翻译后修饰，在细胞信号转导、核质运输与转......
Sensitive to proton rhizotoxicity 1(STOP1) functions as a crucial regulator of root growth during aluminum(Al) stress. H......
Protein modification by small ubiquitin-like modifier(SUMO)is an important regulatory mechanism for multiple cellular pr......
Microtubules (MTs) are regulated by a number of known posttranslational modifications (PTMs) on α/β-tubulin to fulfill......
在后基因组时代,蛋白质组学是一个非常重要的研究内容。蛋白质作为一种基础物质是直接参与了人类的生命活动,通常需要通过进行翻译......
Identification of sumoylated targets in proliferating mouse spermatogonia and human testicular semin
Spermatogenesis is regulated by a complex network of posttranslation modifications.Sumoylation (a modification by small ......
,SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubi
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Objective:Small ubiquitin-related modifiers (SUMOs) are a group of post-translational modification proteins extensively ......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
目的 探讨低氧条件下Jurkat细胞低氧诱导因子-1α(HIF-1α)类泛素化的变化对其基因转录活性和蛋白稳定性的影响,以及对下游靶基因......
小分子泛素相关修饰物(small ubiquitin-related modifier,SUMO)化修饰在真核细胞中广泛存在,参与了多种信号转导和代谢途径。规模......
Objective This study elucidated the function and role of SUMOylation in type I endometrial carcinoma. Methods Fifty type......
目的：探讨Kif18A的 SUMO化修饰及其调控机制。方法在 HEK293T 细胞中共转染Flag－Kif18A、HA －SUMO1或 His －SUMO1质粒，免疫沉淀富集Flag......
目的：探索糖尿病是否可以通过心肌组织肌浆网钙转运三磷酸腺苷（ATP）酶（SERCA2a）的小泛素样修饰进而影响SERCA2a的活性与表达。 方法：采......
肿瘤是一种基因病,涉及到癌基因的激活和/或抑癌基因的失活。在这些基因中,某个或某些基因可能起了关键作用,其通过对下游细胞信号......
